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Umich endnote free11/8/2022 ![]() ![]() 8, 9 Laser-based therapies for ablation of vessels are non-pharmacological therapies that have been used to target CNV. 7 However, none of these pharmacological treatments can permanently cure CNV, and they also have many side-effects, including glaucoma and infection. PUT can remove CNV safely and effectively.Ĭurrently, anti-inflammatory and anti-vascular endothelial growth factor medications are the mainstay therapies for treating significant CNV. These results demonstrate that PUT is capable of removing CNV safely and effectively in this rabbit model. Safety evaluations showed that PUT did not cause any damage to the surrounding tissue. In contrast, 71.4% ± 7.2% of the CNV remained in the control group after 30 days. ![]() In the PUT group, only 1.8% ± 0.8% of the CNV remained 30 days after treatment. For comparison with the PUT safety results, conventional laser photocoagulation (LP) treatment was performed with standard clinical parameters: 532-nm continuous-wave (CW) laser with 0.1-second pulse duration, 450-mW power, and 75-µm spot size. Safety was evaluated by histology and immunohistochemistry. Red-free photography and fluorescein angiography were utilized to evaluate the efficiency of PUT. For the PUT group, the applied light fluence at the corneal surface was estimated to be 27 mJ/cm 2 at 1064-nm wavelength with a pulse duration of 5 ns, and the ultrasound pressure applied on the cornea was 0.43 MPa at 0.5 MHz. We developed a novel treatment method, termed photo-mediated ultrasound therapy (PUT), that combines laser and ultrasound, and we tested its feasibility for treating CNV in a rabbit model.Ī suture-induced CNV model was established in New Zealand White rabbits, which were randomly divided into two groups: PUT and control. Current treatment options for CNV are limited. Corneal neovascularization (CNV) is the invasion of new blood vessels into the avascular cornea, leading to reduced corneal transparency and visual acuity, impaired vision, and even blindness. ![]()
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